Founded in 1640, Quogue is one of the oldest communities on Long Island. In 1659, John Ogden purchased lands in the Quogue area from the Indian sachem Wyandanch. Soon after the lands changed hands and became European settler territory, the Native American name of Quaquanantuck was shortened and changed to Quogue. By the 1790 census, there were only 12 families living in Quogue.

In 1835, Quogue was the second regular overnight stop on the stagecoach run from Brooklyn to Southampton. When railroad service reached Riverhead in 1844, summer boarders began pouring into oceanside communities such as Quogue. Locals refer to the time when wealthy New Yorkers came east once the weather got warm and rented rooms at hotels and rooming houses as the "boarding house era." This era lasted well into the early 1900s and also ushered in a building boom when the regular summer boarders began building homes of their own. The Village of Quogue was incorporated in 1928 and remains part of the Town of Southampton.